… progenitor cells to terminally differentiate, we induced RUNX1-… Cdkn1c encodes the cell
cycle inhibitor p57 Kip2 which is … -EVI1 target genes and an activation of the hematopoietic …

… caused by the inhibition of cell cycle progression, which the … cell cycle and the failure of
hematopoietic progenitor cells to … activation: Left panel: Transcriptional activation of the EVI1 …

… , the transcriptional activation of EVI1 usually … EVI1 in hematopoietic progenitor cells. They
showed that inducible expression of EVI1 leads to cell cycle arrest in G0/G1 in hematopoietic …

… FLAG-tagged EVI1 into murine HSCs and progenitor cells followed by … the EVI1 binding motif
was not required for the activation (… Knockdown of Erg led to cell cycle arrest and apoptosis (…

… EVI1 expression in primary mouse myeloid progenitor cells … of Evi1 in the mouse bone marrow
cell line 32Dcl3 inhibits … As noted above, in two cases where gene therapy activated EVI1 …

… Activation of Evi1 gene expression is capable to inhibit the differentiation of haematopoietic
progenitor cells [… of cell cycle provided a explanation for 1,4-BQ to inhibit cell proliferation in …

… for differences in median expression between Evi1-WT and … selective CDK3 and other
inhibitors would be necessary for … patterns in haematopoietic progenitor cells as assessed by 5-…

… progenitor cells to sustain life-long hematopoiesis. Deregulation of this process, however,
may lead to loss of stem cell … targets Hoxa and inhibits HSC differentiation and cell cycle entry, …

… progenitor cells during normal hematopoiesis. This transition was accompanied by transcriptional
activation of cell cycle … degraders and protein interaction inhibitors provide a promising …

… morphological difference was observed between control and EVI1 … Similarly, EVI1 activation
and its negative effect on cell cycle … progenitor cells [36], where EVI1 activation inhibited cell …